Literaturnachweis - Detailanzeige
Autor/inn/en | Twining, Robert C.; Tuscher, Jennifer J.; Doncheck, Elizabeth M.; Frick, Karyn M.; Mueller, Devin |
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Titel | 17ß-Estradiol Is Necessary for Extinction of Cocaine Seeking in Female Rats |
Quelle | In: Learning & Memory, 20 (2013) 6, S.300-306 (4 Seiten)
PDF als Volltext |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 1072-0502 |
DOI | 10.1101/lm.030304.113 |
Schlagwörter | Animals; Females; Cocaine; Learning Processes; Animal Behavior; Conditioning; Biochemistry |
Abstract | Human and preclinical models of addiction demonstrate that gonadal hormones modulate acquisition of drug seeking. Little is known, however, about the effects of these hormones on extinction of drug-seeking behavior. Here, we investigated how 17ß-estradiol (E[subscript 2]) affects expression and extinction of cocaine seeking in female rats. Using a conditioned place preference (CPP) paradigm, ovariectomized rats were maintained throughout conditioning with 2 d of E[subscript 2] treatment followed by 2 d of vehicle treatment, or were injected with E[subscript 2] daily. Hormone injections were paired or explicitly unpaired with place conditioning sessions. Expression of a cocaine CPP was of equal magnitude regardless of conditioning protocol, suggesting that E[subscript 2] levels during conditioning did not affect subsequent CPP expression. During extinction, daily E[subscript 2] administration initially enhanced expression of the cocaine CPP, but resulted in significantly faster extinction compared to controls. Whereas E[subscript 2]-treated rats were extinguished within 8 d, vehicle-treated rats maintained CPP expression for more than a month, indicative of perseveration. To determine whether E[subscript 2] could rescue extinction in these rats, half were given daily E[subscript 2] treatment and half were given vehicle. E[subscript 2]-treated rats showed rapid extinction, whereas vehicle-treated rats continued to perseverate. These data demonstrate for the first time that E[subscript 2] is necessary for extinction of cocaine seeking in female rats, and that it promotes rapid extinction when administered daily. Clinically, these findings suggest that monitoring and maintaining optimal E[subscript 2] levels during exposure therapy would facilitate therapeutic interventions for female cocaine addicts. (As Provided). |
Anmerkungen | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2017/4/10 |