Iron and ADHD: Time to Move beyond Serum Ferritin Levels

Autor/inn/en	Donfrancesco, Renato; Parisi, Pasquale; Vanacore, Nicola; Martines, Francesca; Sargentini, Vittorio; Cortese, Samuele
Titel	Iron and ADHD: Time to Move beyond Serum Ferritin Levels
Quelle	In: Journal of Attention Disorders, 17 (2013) 4, S.347-357 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1087-0547
DOI	10.1177/1087054711430712
Schlagwörter	Comparative Analysis; Attention Deficit Hyperactivity Disorder; Control Groups; Biochemistry; Symptoms (Individual Disorders); Severity (of Disability); Children; Correlation; Neurology; Biology; Brain; Evaluation Methods; Intelligence Quotient; Statistical Analysis; Foreign Countries; Italy (Rome); Wechsler Intelligence Scale for Children + Suchen Sie Ihr Suchwort? Biochemie; Psychiatrische Symptomatik; Schweregrad; Child; Kind; Kinder; Korrelation; Neurologie; Biologie; Gehirn; Intelligenzquotient; Statistische Analyse; Ausland
Abstract	Objective: (a) To compare serum ferritin levels in a sample of stimulant-naive children with ADHD and matched controls and (b) to assess the association of serum ferritin to ADHD symptoms severity, ADHD subtypes, and IQ. Method: The ADHD and the control groups included 101 and 93 children, respectively. Serum ferritin levels were determined with the enzyme-linked immunosorbent assay method. Results: Serum ferritin did not significantly differ between children with ADHD and controls, as well as among ADHD subtypes. Correlations between serum ferritin levels and measures related to IQ or ADHD severity were not significant. Conclusion: This is the largest controlled study that assessed ferritin levels in stimulant-naive ADHD children. The findings of this study do not support a significant relationship between serum ferritin levels and ADHD. However, the authors' results based on peripheral measures of iron do not rule out a possible implication of brain iron deficiency in ADHD, grounded on neurobiological hypotheses and preliminary empirical evidence. (Contains 4 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10