DNA Methylation: A Mechanism for Embedding Early Life Experiences in the Genome

Autor/inn/en	Szyf, Moshe; Bick, Johanna
Titel	DNA Methylation: A Mechanism for Embedding Early Life Experiences in the Genome
Quelle	In: Child Development, 84 (2013) 1, S.49-57 (9 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0009-3920
DOI	10.1111/j.1467-8624.2012.01793.x
Schlagwörter	Genetics; Early Experience; Individual Development; Cytology; Change; Environmental Influences; Research; Child Development; Stress Variables; Brain + Suchen Sie Ihr Suchwort? Humangenetik; Frühbeginn; Individuelle Entwicklung; Zytologie; Wandel; Environmental influence; Umwelteinfluss; Forschung; Kindesentwicklung; Gehirn
Abstract	Although epidemiological data provide evidence that early life experience plays a critical role in human development, the mechanism of how this works remains in question. Recent data from human and animal literature suggest that epigenetic changes, such as DNA methylation, are involved not only in cellular differentiation but also in the modulation of genome function in response to early life experience affecting gene function and the phenotype. Such modulations may serve as a mechanism for life-long genome adaptation. These changes seem to be widely distributed across the genome and to involve central and peripheral systems. Examining the environmental circumstances associated with the onset and reversal of DNA methylation will be critical for understanding risk and resiliency. (Contains 4 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10