Gene Expression in the Human Brain: The Current State of the Study of Specificity and Spatiotemporal Dynamics

Autor/inn/en	Naumova, Oksana Yu.; Lee, Maria; Rychkov, Sergei Yu.; Vlasova, Natalia V.; Grigorenko, Elena L.
Titel	Gene Expression in the Human Brain: The Current State of the Study of Specificity and Spatiotemporal Dynamics
Quelle	In: Child Development, 84 (2013) 1, S.76-88 (13 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0009-3920
DOI	10.1111/cdev.12014
Schlagwörter	Brain; Genetics; Brain Hemisphere Functions; Molecular Structure; Scientific Research; Research Methodology; Molecular Biology; Anatomy; Infants; Pregnancy; Aging (Individuals); Child Development; Developmental Stages + Suchen Sie Ihr Suchwort? Gehirn; Humangenetik; Research method; Forschungsmethode; Molekularbiologie; Anatomie; Infant; Toddler; Toddlers; Kleinkind; Schwangerschaft; Aging; Altern; Kindesentwicklung
Abstract	Gene expression is one of the main molecular processes regulating the differentiation, development, and functioning of cells and tissues. In this review a handful of relevant terms and concepts are introduced and the most common techniques used in studies of gene expression/expression profiling (also referred to as studies of the transcriptome or transcriptomics) are described. The main foci of this review are the advancements in studies of the transcriptome in the human brain, the transcriptome's variability across different brain structures, and the systematic changes that occur through different developmental stages across the life span in general and childhood in particular. Finally, the question of how the accumulating data on the spatial and temporal dynamics of the transcriptome may shed light on the molecular mechanisms of the typical and atypical development of the central nervous system is addressed. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10