Association between Plasma Levels of Transforming Growth Factor-beta1, IL-23 and IL-17 and the Severity of Autism in Egyptian Children

Autor/inn/en	Hashim, Haitham; Abdelrahman, Hadeel; Mohammed, Doaa; Karam, Rehab
Titel	Association between Plasma Levels of Transforming Growth Factor-beta1, IL-23 and IL-17 and the Severity of Autism in Egyptian Children
Quelle	In: Research in Autism Spectrum Disorders, 7 (2013) 1, S.199-204 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1750-9467
DOI	10.1016/j.rasd.2012.08.007
Schlagwörter	Rating Scales; Autism; Foreign Countries; Control Groups; Severity (of Disability); Correlation; Metabolism; Diseases; Children; Comparative Analysis; Egypt; Childhood Autism Rating Scale + Suchen Sie Ihr Suchwort? Rating-Skala; Autismus; Ausland; Schweregrad; Korrelation; Stoffwechsel; Disease; Krankheit; Child; Kind; Kinder; Ägypten
Abstract	It has been recently shown that dysregulation of transforming growth factor-beta1 (TGF-beta1), IL-23 and IL-17 has been identified as a major factor involved in autoimmune disorders. Based on the increasing evidence of immune dysfunction in autism the aim of this study was to measure serum levels of TGF-beta1, IL-23 and IL-17 in relation to the degree of the severity of autism. Serum TGF-beta1, IL-23 and IL-17 were measured by Enzyme-linked Immunosorbent Assay technique in 50 autistic children aged 6-12 years, in comparison to 50 developmental disabilities and 50 typically developing-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale. We found that TGF-beta1 and IL-23 levels were significantly decreased in the plasma of children with ASD in comparison to control groups (P less than 0.0001 for both) with no significant difference in IL-17 levels. There was no correlation between IL-23 and TGF-beta1 with IL-17 in children with ASD. There was a negative correlation between TGF-beta1, IL-23 and IL-17 with the severity of autism (P less than 0.0001, 0.0001, 0.005 respectively). Our results support the findings that immune dysfunction may occur in some children with autism. (Contains 3 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10