Brief Report: CANTAB Performance and Brain Structure in Pediatric Patients with Asperger Syndrome

Autor/inn/en	Kaufmann, Liane; Zotter, Sibylle; Pixner, Silvia; Starke, Marc; Haberlandt, Edda; Steinmayr-Gensluckner, Maria; Egger, Karl; Schocke, Michael; Weiss, Elisabeth M.; Marksteiner, Josef
Titel	Brief Report: CANTAB Performance and Brain Structure in Pediatric Patients with Asperger Syndrome
Quelle	In: Journal of Autism and Developmental Disorders, 43 (2013) 6, S.1483-1490 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-012-1686-6
Schlagwörter	Brain; Neurology; Autism; Asperger Syndrome; Patients; Short Term Memory; Neuropsychology; Executive Function; Correlation + Suchen Sie Ihr Suchwort? Gehirn; Neurologie; Autismus; Asperger-Syndrom; Patient; Kurzzeitgedächtnis; Neuropsychologie; Korrelation
Abstract	By merging neuropsychological (CANTAB/Cambridge Neuropsychological Test Automated Battery) and structural brain imaging data (voxel-based-morphometry) the present study sought to identify the neurocognitive correlates of executive functions in individuals with Asperger syndrome (AS) compared to healthy controls. Results disclosed subtle group differences regarding response speed on only one CANTAB subtest that is thought to tap fronto-executive network functions (SWM/spatial working memory). Across all participants, SWM performance was significantly associated with two brain regions (precentral gyrus white matter, precuneus grey matter), thus suggesting a close link between fronto-executive functions (SWM) and circumscribed fronto-parietal brain structures. Finally, symptom severity (ADOS total score) was best predicted by response speed on a set-shifting task (IES) thought to tap fronto-striatal functions (corrected R[squared] 56 %). (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10