Individualised stepwise adaptive treatment for 3-6-year-old preschool children impaired by attention-deficit/hyperactivity disorder (ESCApreschool): study protocol of an adaptive intervention study including two randomised controlled trials within the consortium ESCAlife.

Autor/Urheber	Becker, Katja; Banaschewski, Tobias; Brandeis, Daniel; Dose, Christina; Hautmann, Christopher; Holtmann, Martin; Jans, Thomas; Jendreizik, Lea; Jenkner, Carolin; John, Katja; Ketter, Johanna; Millenet, Sabina; Pauli-Pott, Ursula; Renner, Tobias; Romanos,
Institution	BioMed Central
Titel	Individualised stepwise adaptive treatment for 3-6-year-old preschool children impaired by attention-deficit/hyperactivity disorder (ESCApreschool): study protocol of an adaptive intervention study including two randomised controlled trials within the consortium ESCAlife.
Quelle	In: doi:10.5167/uzh-181528; doi:10.1186/s13063-019-3872-8; info:pmid/31918739; urn:issn:1745-6215; Becker, Katja; Banaschewski, Tobias; Brandeis, Daniel; Dose, Christina; Hautmann, Christopher; Holtmann, Martin; Jans, Thomas; Jendreizik, Lea; Jenkner, Carolin; John, Katja; Ketter, Johanna; Millenet, Sabina; Pauli-Pott, Ursula; Renner, Tobias; Romanos, Marcel; Treier, Anne-Katrin; von Wirth, Elena; Wermter, Anne-Kathrin; Döpfner, Manfred (2020). Individualised stepwise adaptive treatment for 3-6-year-old preschool children impaired by attention-deficit/hyperactivity disorder (ESCApreschool): study protocol of an adaptive intervention study including two randomised controlled trials within the consortium ESCAlife. Trials, 21(1):56.(2020) PDF als Volltext kostenfreie Datei
Sprache	englisch
Dokumenttyp	online; Zeitschriftenaufsatz
DOI	10.5167/uzh-181528
Schlagwörter	Department of Child and Adolescent Psychiatry; 610 Medicine & health; ADHD; Adaptive treatment; Attention-deficit/hyperactivity disorder; Behaviour therapy; ESCAlife; Kindergarten; Preschool children; Stepped care; Telephone-assisted self-help
Abstract	BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a psychosocially impairing and cost-intensive mental disorder, with first symptoms occurring in early childhood. It can usually be diagnosed reliably at preschool age. Early detection of children with ADHD symptoms and an early, age-appropriate treatment are needed in order to reduce symptoms, prevent secondary problems and enable a better school start. Despite existing ADHD treatment research and guideline recommendations for the treatment of ADHD in preschool children, there is still a need to optimise individualised treatment strategies in order to improve outcomes. Therefore, the ESCApreschool study (Evidence-Based, Stepped Care of ADHD in Preschool Children aged 3 years and 0 months to 6 years and 11 months of age (3;0 to 6;11 years) addresses the treatment of 3-6-year-old preschool children with elevated ADHD symptoms within a large multicentre trial. The study aims to investigate the efficacy of an individualised stepwise-intensifying treatment programme. METHODS: The target sample size of ESCApreschool is 200 children (boys and girls) aged 3;0 to 6;11 years with an ADHD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) or a diagnosis of oppositional defiant disorder (ODD) plus additional substantial ADHD symptoms. The first step of the adaptive, stepped care design used in ESCApreschool consists of a telephone-assisted self-help (TASH) intervention for parents. Participants are randomised to either the TASH group or a waiting control group. The treatment in step 2 depends on the outcome of step 1: TASH responders without significant residual ADHD/ODD symptoms receive booster sessions of TASH. Partial or non-responders of step 1 are randomised again to either parent management and preschool teacher training or treatment as usual. DISCUSSION: The ESCApreschool trial aims to improve knowledge about individualised treatment strategies for preschool children with ADHD following an adaptive stepped care approach, and to provide a scientific basis for individualised medicine for preschool children with ADHD in routine clinical care. TRIAL REGISTRATION: The trial was registered at the German Clinical Trials Register (DRKS) as a Current Controlled Trial under DRKS00008971 on 1 October 2015. This manuscript is based on protocol version 3 (14 October 2016).
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