Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity.

Autor/inn/en	Schulz, André; Deuter, Christian E.; Breden, Ion-Hideo; Vögele, Claus; Wingenfeld, Katja; Otte, Christian; Kuehl, Linn K.
Titel	Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity. Gefälligkeitsübersetzung: Die durch Yohimbin ausgelöste noradrenerge Aktivierung vermindert die interozeptive Genauigkeit bei gesunden Personen mit belastenden Kindheitserfahrungen.
Quelle	In: Development and psychopathology, 34 (2022) 3, S. 1013-1024 PDF als Volltext kostenfreie Datei Link als defekt meldenVerfügbarkeit
Sprache	englisch
Dokumenttyp	online; gedruckt; Zeitschriftenaufsatz
ISSN	0954-5794; 1469-2198
DOI	10.1017/S0954579420001613
Schlagwörter	Erfahrung; Depression; Interozeption; Trauma (Psy); Frühe Kindheit; Kindheit; Adrenalin; Rezeptor; Stress; Blutdruck; Herzfrequenz; Schwierigkeit
Abstract	Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamic-pituitary-adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group × Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE. (ZPID).
Erfasst von	Leibniz-Institut für Psychologie, Trier
Update	2024/1