Highs and lows. Genetic susceptibility to daily events.

Autor/inn/en	Sicorello, Maurizio; Dieckmann, Linda; Moser, Dirk; Lux, Vanessa; Luhmann, Maike; Neubauer, Andreas B.; Schlotz, Wolff; Kumsta, Robert
Titel	Highs and lows. Genetic susceptibility to daily events.
Quelle	In: PLOS ONE, 15 (2020) 8, Art. e0237001, 17 S. PDF als Volltext kostenfreie Datei Link als defekt meldenVerfügbarkeit
Sprache	englisch
Dokumenttyp	online; Zeitschriftenaufsatz
ISSN	1932-6203
DOI	10.1371/journal.pone.0237001
Schlagwörter	Emotion; Person; Verhaltensgenetik; Belastung; Bochum; Deutschland; Serotonin; Gen; Person; Ereignis; Verhaltensgenetik; Smartphone; Gen; Serotonin; Belastung; Einflussfaktor; Ereignis; Umgebung; Smartphone; Online; Bochum; Deutschland
Abstract	Why people differ in their susceptibility to external events is essential to our understanding of personality, human development, and mental disorders. Genes explain a substantial portion of these differences. Specifically, genes influencing the serotonin system are hypothesized to be differential susceptibility factors, determining a person's reactivity to both positive and negative environments. We tested whether genetic variation in the serotonin transporter (5-HTTLPR) is a differential susceptibility factor for daily events. Participants (N = 326, 77% female, mean age = 25, range = 17-36) completed smartphone questionnaires four times a day over four to five days, measuring stressors, uplifts, positive and negative affect. Affect was predicted from environment valence in the previous hour on a within-person level using three-level autoregressive linear mixed models. The 5-HTTLPR fulfilled all criteria of a differential susceptibility factor: Positive affect in carriers of the short allele (S) was less reactive to both uplifts and stressors, compared to homozygous carriers of the long allele (L/L). This pattern might reflect relative affective inflexibility in S-allele carriers. Our study provides insight into the serotonin system's general role in susceptibility and highlights the need to assess the whole spectrum of naturalistic experiences.
Erfasst von	DIPF \| Leibniz-Institut für Bildungsforschung und Bildungsinformation, Frankfurt am Main
Update	2021/3