Annual Research Review: Development of the Cerebral Cortex--Implications for Neurodevelopmental Disorders

Autor/in	Rubenstein, John L. R.
Titel	Annual Research Review: Development of the Cerebral Cortex--Implications for Neurodevelopmental Disorders
Quelle	In: Journal of Child Psychology and Psychiatry, 52 (2011) 4, S.339-355 (17 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2010.02307.x
Schlagwörter	Anatomy; Brain Hemisphere Functions; Cognitive Processes; Mental Disorders; Genetics; Molecular Biology; Cytology; Autism; Neurology + Suchen Sie Ihr Suchwort? Anatomie; Cognitive process; Kognitiver Prozess; Mental illness; Geisteskrankheit; Humangenetik; Molekularbiologie; Zytologie; Autismus; Neurologie
Abstract	The cerebral cortex has a central role in cognitive and emotional processing. As such, understanding the mechanisms that govern its development and function will be central to understanding the bases of severe neuropsychiatric disorders, particularly those that first appear in childhood. In this review, I highlight recent progress in elucidating genetic, molecular and cellular mechanisms that control cortical development. I discuss basic aspects of cortical developmental anatomy, and mechanisms that regulate cortical size and area formation, with an emphasis on the roles of fibroblast growth factor (Fgf) signaling and specific transcription factors. I then examine how specific types of cortical excitatory projection neurons are generated, and how their axons grow along stereotyped pathways to their targets. Next, I address how cortical inhibitory (GABAergic) neurons are generated, and point out the role of these cells in controlling cortical plasticity and critical periods. The paper concludes with an examination of four possible developmental mechanisms that could contribute to some forms of neurodevelopmental disorders, such as autism. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10