Facilitation of Memory for Extinction of Drug-Induced Conditioned Reward: Role of Amygdala and Acetylcholine

Autor/inn/en	Schroeder, Jason P.; Packard, Mark G.
Titel	Facilitation of Memory for Extinction of Drug-Induced Conditioned Reward: Role of Amygdala and Acetylcholine
Quelle	In: Learning & Memory, 11 (2004) 5, S.641-647 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.78504
Schlagwörter	Rewards; Memory; Behavior Modification; Biochemistry; Pharmacology; Drug Use; Laboratory Procedures; Animals; Animal Behavior; Behavioral Science Research; Brain; Drug Addiction + Suchen Sie Ihr Suchwort? Reward; Belohnung; Gedächtnis; Behaviour modification; Verhaltensänderung; Biochemie; Arzneikunde; Drug consumption; Substance abuse; Drogenkonsum; Laboruntersuchung; Animal; Tier; Tiere; Tierverhalten; Gehirn; Drug dependence; Drug consomption; Drogenabhängigkeit
Abstract	eThese experiments examined the effects of posttrial peripheral and intra-amygdala injections of the cholinergic muscarinic receptor agonist oxotremorine on memory consolidation underlying extinction of amphetamine conditioned place preference (CPP) behavior. Male Long-Evans rats were initially trained and tested for an amphetamine (2 mg/kg) CPP. Rats were subsequently given limited extinction training, followed by immediate posttrial peripheral or intrabasolateral amygdala injections of oxotremorine. A second CPP test was then administered, and the amount of time spent in the previously amphetamine-paired and saline-paired apparatus compartments was recorded. Peripheral (0.07 or 0.01 mg/kg) or intra-amygdala (10 [eta]g/0.5[mu]L) postextinction trial injections of oxotremorine facilitated CPP extinction. Oxotremorine injections that were delayed 2 h posttrial training did not enhance CPP extinction, indicating a time-dependent effect of the drug on memory consolidation processes. The findings indicate that memory consolidation for extinction of approach behavior to environmental stimuli previously paired with drug reward can be facilitated by posttrial peripheral or intrabasolateral amygdala administration of a cholinergic agonist. (Contains 3 figures.) (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10