Recent Developments in Transcriptional and Translational Regulation Underlying Long-Term Synaptic Plasticity and Memory

Autor/inn/en	Hegde, Ashok N.; Smith, Spencer G.
Titel	Recent Developments in Transcriptional and Translational Regulation Underlying Long-Term Synaptic Plasticity and Memory
Quelle	In: Learning & Memory, 26 (2019) 9, S.307-317 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.048769.118
Schlagwörter	Memory; Brain Hemisphere Functions; Biochemistry; Molecular Structure; Genetics; Identification; Diagnostic Tests + Suchen Sie Ihr Suchwort? Gedächtnis; Biochemie; Humangenetik; Identifikation; Identifizierung; Diagnostic test; Diagnostischer Test
Abstract	Formation of long-term synaptic plasticity that underlies long-term memory requires new protein synthesis. Years of research has elucidated some of the transcriptional and translational mechanisms that contribute to the production of new proteins. Early research on transcription focused on the transcription factor cAMP-responsive element binding protein. Since then, other transcription factors, such as the Nuclear Receptor 4 family of proteins that play a role in memory formation and maintenance have been identified. In addition, several studies have revealed details of epigenetic mechanisms consisting of new types of chemical alterations of DNA such as hydroxymethylation, and various histone modifications in long-term synaptic plasticity and memory. Our understanding of translational control critical for memory formation began with the identification of molecules that impinge on the 5' and 3' untranslated regions of mRNAs and continued with the appreciation for local translation near synaptic sites. Lately, a role for noncoding RNAs such as microRNAs in regulating translation factors and other molecules critical for memory has been found. This review describes the past research in brief and mainly focuses on the recent work on molecular mechanisms of transcriptional and translational regulation that form the underpinnings of long-term synaptic plasticity and memory. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01