Nitric Oxide and Interlukin-6 Levels in Intellectual Disability Adults with Epilepsy

Autor/inn/en	Carmeli, Eli; Beiker, Reut; Morad, Mohammed
Titel	Nitric Oxide and Interlukin-6 Levels in Intellectual Disability Adults with Epilepsy
Quelle	In: Research in Developmental Disabilities: A Multidisciplinary Journal, 30 (2009) 3, S.567-571 (5 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0891-4222
DOI	10.1016/j.ridd.2008.08.004
Schlagwörter	Epilepsy; Mental Retardation; Seizures; Evaluation; Adults; Neurological Impairments; Sleep + Suchen Sie Ihr Suchwort? Epilepsie; Geistige Behinderung; Anfallsleiden; Evaluierung; Neurodegenerative Erkrankung; Schlaf
Abstract	Nitric oxide (NO) and interlukin-6 (IL-6) are highly reactive mediators that have been shown to play different roles in a variety of different biological process. The role of NO and IL-6 in the neuropathogenesis of brain seizures is still questionable. In order to evaluate the role of NO and IL-6 in neurological disorders such as seizures, we investigated 19 adults with intellectual disability (ID) who suffer from epilepsy and treated for convulsions. NO metabolites (NOx) and IL-6 levels in serum obtained after night-sleep were significantly high among ID individuals diagnosed with epilepsy versus ID people without epilepsy. These results indicated that NOx and IL-6 may have a pathophysiological role in convulsions. Consequently, we suggest that professionals consider chemical inhibitors that might be helpful against the function of NO and IL-6. (Contains 1 figure and 1 table.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10