Resting-State Oscillatory Activity in Autism Spectrum Disorders

Autor/inn/en	Cornew, Lauren; Roberts, Timothy P. L.; Blaskey, Lisa; Edgar, J. Christopher
Titel	Resting-State Oscillatory Activity in Autism Spectrum Disorders
Quelle	In: Journal of Autism and Developmental Disorders, 42 (2012) 9, S.1884-1894 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-011-1431-6
Schlagwörter	Autism; Severity (of Disability); Pervasive Developmental Disorders; Brain Hemisphere Functions; Diagnostic Tests; Children; Neurological Impairments; Symptoms (Individual Disorders) + Suchen Sie Ihr Suchwort? Autismus; Schweregrad; Diagnostic test; Diagnostischer Test; Child; Kind; Kinder; Neurodegenerative Erkrankung; Psychiatrische Symptomatik
Abstract	Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and high frequency (20-120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10