The Effect of Temperature on the Enzyme-Catalyzed Reaction: Insights from Thermodynamics

Autor/inn/en	Aledo, Juan Carlos; Jimenez-Riveres, Susana; Tena, Manuel
Titel	The Effect of Temperature on the Enzyme-Catalyzed Reaction: Insights from Thermodynamics
Quelle	In: Journal of Chemical Education, 87 (2010) 3, S.296-298 (3 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/ed800088n
Schlagwörter	Scientific Concepts; Thermodynamics; Biochemistry; Science Instruction; Models; Metabolism; Molecular Structure; Climate; Animals + Suchen Sie Ihr Suchwort? Thermodynamik; Biochemie; Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Analogiemodell; Stoffwechsel; Klima; Animal; Tier; Tiere
Abstract	When teaching the effect of temperature on biochemical reactions, the problem is usually oversimplified by confining the thermal effect to the catalytic constant, which is identified with the rate constant of the elementary limiting step. Therefore, only positive values for activation energies and values greater than 1 for temperature coefficients ("Q"[subscript 10], defined as the rate change that parallels a 10 [degree]C temperature shift) can be expected. We show why this approach, which is appropriate under saturation conditions, is unsuitable for those enzymes working at subsaturating concentrations of their substrates. To overcome this limitation, we present and discuss a simple thermokinetic treatment of the Michaelis-Menten model for the enzyme-catalyzed reaction. (Contains 1 figure.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10