Functional Connectivity: A Source of Variance in the Association between Cardiorespiratory Fitness and Cognition?

Autor/inn/en	Voss, Michelle W.; Erickson, Kirk I.; Prakash, Ruchika S.; Chaddock, Laura; Malkowski, Edward; Alves, Heloisa; Kim, Jennifer S.; Morris, Katherine S.; White, Siobhan M.; Wojcicki, Thomas R.; Hu, Liang; Szabo, Amanda; Klamm, Emily; McAuley, Edward; Kramer, Arthur F.
Titel	Functional Connectivity: A Source of Variance in the Association between Cardiorespiratory Fitness and Cognition?
Quelle	In: Neuropsychologia, 48 (2010) 5, S.1394-1406 (13 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2010.01.005
Schlagwörter	Alzheimers Disease; Public Health; Physical Fitness; Diseases; Cognitive Ability; Older Adults; Age Differences; Correlation; Aging (Individuals); Neurology; Biology + Suchen Sie Ihr Suchwort? Gesundheitswesen; Leistungsfähigkeit; Disease; Krankheit; Denkfähigkeit; Älterer Erwachsener; Age; Difference; Age difference; Altersunterschied; Korrelation; Aging; Altern; Neurologie; Biologie
Abstract	Over the next 20 years the number of Americans diagnosed with dementia is expected to more than double (CDC, 2007). It is, therefore, an important public health initiative to understand what factors contribute to the longevity of a healthy mind. Both default mode network (DMN) function and increased aerobic fitness have been associated with better cognitive performance and reduced incidence of Alzheimer's disease among older adults. Here we examine the association between aerobic fitness, functional connectivity in the DMN, and cognitive performance. Results showed significant age-related deficits in functional connectivity in both local and distributed DMN pathways. However, in a group of healthy elderly adults, almost half of the age-related disconnections showed increased functional connectivity as a function of aerobic fitness level. Finally, we examine the hypothesis that functional connectivity in the DMN is one source of variance in the relationship between aerobic fitness and cognition. Results demonstrate instances of both specific and global DMN connectivity mediating the relationship between fitness and cognition. We provide the first evidence for functional connectivity as a source of variance in the association between aerobic fitness and cognition, and discuss results in the context of neurobiological theories of cognitive aging and disease. (Contains 2 tables and 3 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10