An Exploratory Study on DRD2 and Creative Potential

Autor/inn/en	Zhang, Shun; Zhang, Muzi; Zhang, Jinghuan
Titel	An Exploratory Study on DRD2 and Creative Potential
Quelle	In: Creativity Research Journal, 26 (2014) 1, S.115-123 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1040-0419
DOI	10.1080/10400419.2014.874267
Schlagwörter	Genetics; Creativity; Foreign Countries; Undergraduate Students; Creative Thinking; Creativity Tests; Verbal Ability; Verbal Tests; Correlation; Intelligence Tests; Research Methodology; Discovery Processes; China; Raven Advanced Progressive Matrices + Suchen Sie Ihr Suchwort? Humangenetik; Kreativität; Ausland; Kreatives Denken; Creativity test; Kreativitätstest; Mündliche Leistung; Mündliche Prüfung; Korrelation; Intelligence test; Intelligenztest; Research method; Forschungsmethode
Abstract	One critical step toward to a better understanding of creativity is to unveil its underlying genetic architectures. Recently, several studies have been conducted to investigate the effects of dopamine (DA) and 5-hydroxytryptamine (5-HT) related genetic polymorphisms on creativity. Among DA related genes, dopamine D2 receptor gene ("DRD2") is one of the most promising candidate genes for creativity. This study systematically explored the associations between "DRD2" genetic polymorphisms and creative potential in the Han Chinese population. Fifteen single-nucleotide polymorphisms (SNPs) covering "DRD2" were genotyped in 543 unrelated healthy Chinese undergraduate students whose creative potentials were assessed by divergent thinking (DT) tests. Single SNP analysis showed that, for verbal DT tests, 7 SNPs (rs4648319, rs2283265, rs1076560, rs6276, rs6279, rs6278, and rs1800497) showed significant associations with verbal fluency, and 2 SNPs (rs6277 and rs7122246) showed significant associations with verbal originality. For figural DT tests, 5 SNPs (rs2283265, rs6276, rs6279, rs6278 and rs1800497) showed significant associations with figural fluency, and 2 SNPs (rs6278 and rs1800497) showed significant associations with figural flexibility. Haplotype analysis showed that the 10-SNP haplotype consisting of rs4648319, rs4436578, rs7122246, rs2283265, rs1076560, rs6277, rs6276, rs6279, rs6278, and rs1800497 was significantly associated with verbal fluency. In conclusion, this exploratory study provides preliminary evidence for the involvement of "DRD2" in creative potential. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01