A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABA[subscript A] Receptors

Autor/inn/en	Kang, Jing-Qiong; Barnes, Gregory
Titel	A Common Susceptibility Factor of Both Autism and Epilepsy: Functional Deficiency of GABA[subscript A] Receptors
Quelle	In: Journal of Autism and Developmental Disorders, 43 (2013) 1, S.68-79 (12 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-012-1543-7
Schlagwörter	Pathology; Autism; Symptoms (Individual Disorders); Epilepsy; At Risk Persons; Genetics; Neurological Impairments; Molecular Structure; Brain Hemisphere Functions + Suchen Sie Ihr Suchwort? Pathologie; Autismus; Psychiatrische Symptomatik; Epilepsie; Risikogruppe; Humangenetik; Neurodegenerative Erkrankung
Abstract	Autism and epilepsy are common childhood neurological disorders with a great heterogeneity of clinical phenotypes as well as risk factors. There is a high co-morbidity of autism and epilepsy. The neuropathology of autism and epilepsy has similar histology implicating the processes of neurogenesis, neural migration, programmed cell death, and neurite outgrowth. Genetic advances have identified multiple molecules that participate in neural development, brain network connectivity, and synaptic function which are involved in the pathogenesis of autism and epilepsy. Mutations in GABA[subscript A] receptor subunit have been frequently associated with epilepsy, autism, and other neuropsychiatric disorders. In this paper, we address the hypothesis that functional deficiency of GABAergic signaling is a potential common molecular mechanism underpinning the co-morbidity of autism and epilepsy. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10