Pilocarpine Seizures Cause Age-Dependent Impairment in Auditory Location Discrimination

Autor/inn/en	Neill, John C.; Liu, Zhao; Mikati, Mohammad; Holmes, Gregory L.
Titel	Pilocarpine Seizures Cause Age-Dependent Impairment in Auditory Location Discrimination
Quelle	In: Journal of the Experimental Analysis of Behavior, 84 (2005) 3, S.357-370 (14 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0022-5002
Schlagwörter	Auditory Discrimination; Seizures; Age Differences; Epilepsy; Animals; Animal Behavior; Behavioral Science Research; Auditory Stimuli; Neurological Impairments + Suchen Sie Ihr Suchwort? Anfallsleiden; Age; Difference; Age difference; Altersunterschied; Epilepsie; Animal; Tier; Tiere; Tierverhalten; Auditive Stimulation; Neurodegenerative Erkrankung
Abstract	Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unknown. A naturalistic auditory location discrimination method was used to evaluate this question using an animal model of status epilepticus. Male Sprague-Dawley rats were injected with saline on postnatal day (P) 20, or a convulsant dose of pilocarpine on P20 or P45. Pilocarpine on either day induced status epilepticus; status epilepticus at P45 resulted in CA3 cell loss and spontaneous seizures, whereas P20 rats had no cell loss or spontaneous seizures. Mature rats were trained with sound-source location and sound-silence discriminations. Control (saline P20) rats acquired both discriminations immediately. In status epilepticus (P20) rats, acquisition of the sound-source location discrimination was moderately impaired. Status epilepticus (P45) rats failed to acquire either sound-source location or sound-silence discriminations. Status epilepticus in rat causes an age-dependent, long-term impairment in auditory discrimination. This impairment may explain one cause of impaired auditory location discrimination in humans. (Contains 1 table and 3 figures.) (As Provided).
Anmerkungen	Society for the Experimental Analysis of Behavior. Available from: Indiana University Department of Psychology. Bloomington, IN 47405. Tel: 812-334-0395; Fax: 812-855-4691; e-mail: jeab@indiana.edu; Web site: http://seab.envmed.rochester.edu/jeab/index.html
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10