Early Behavioral Intervention Is Associated with Normalized Brain Activity in Young Children with Autism

Autor/inn/en	Dawson, Geraldine; Jones, Emily J. H.; Merkle, Kristen; Venema, Kaitlin; Lowy, Rachel; Faja, Susan; Kamara, Dana; Murias, Michael; Greenson, Jessica; Winter, Jamie; Smith, Milani; Rogers, Sally J.; Webb, Sara J.
Titel	Early Behavioral Intervention Is Associated with Normalized Brain Activity in Young Children with Autism
Quelle	In: Journal of the American Academy of Child & Adolescent Psychiatry, 51 (2012) 11, S.1150-1159 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0890-8567
DOI	10.1016/j.jaac.2012.08.018
Schlagwörter	Social Behavior; Autism; Young Children; Intelligence Quotient; Behavior Modification; Early Intervention; Language Acquisition; Pervasive Developmental Disorders; Toddlers; Brain Hemisphere Functions; Diagnostic Tests; Visual Stimuli; Comparative Analysis; Symptoms (Individual Disorders) + Suchen Sie Ihr Suchwort? Social behaviour; Soziales Verhalten; Autismus; Frühe Kindheit; Intelligenzquotient; Behaviour modification; Verhaltensänderung; Sprachaneignung; Spracherwerb; Infant; Infants; Toddler; Kleinkind; Diagnostic test; Diagnostischer Test; Psychiatrische Symptomatik
Abstract	Objective: A previously published randomized clinical trial indicated that a developmental behavioral intervention, the Early Start Denver Model (ESDM), resulted in gains in IQ, language, and adaptive behavior of children with autism spectrum disorder. This report describes a secondary outcome measurement from this trial, EEG activity. Method: Forty-eight 18- to 30-month-old children with autism spectrum disorder were randomized to receive the ESDM or referral to community intervention for 2 years. After the intervention (age 48 to 77 months), EEG activity (event-related potentials and spectral power) was measured during the presentation of faces versus objects. Age-matched typical children were also assessed. Results: The ESDM group exhibited greater improvements in autism symptoms, IQ, language, and adaptive and social behaviors than the community intervention group. The ESDM group and typical children showed a shorter Nc latency and increased cortical activation (decreased alpha power and increased theta power) when viewing faces, whereas the community intervention group showed the opposite pattern (shorter latency event-related potential [ERP] and greater cortical activation when viewing objects). Greater cortical activation while viewing faces was associated with improved social behavior. Conclusions: This was the first trial to demonstrate that early behavioral intervention is associated with normalized patterns of brain activity, which is associated with improvements in social behavior, in young children with autism spectrum disorder. (Contains 5 figures.) (As Provided).
Anmerkungen	Elsevier. 6277 Sea Harbor Drive, Orlando, FL 32887-4800. Tel: 877-839-7126; Tel: 407-345-4020; Fax: 407-363-1354; e-mail: usjcs@elsevier.com; Web site: http://www.elsevier.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10