Vitamin D and Autism: Clinical Review

Autor/inn/en	Kocovska, Eva; Fernell, Elisabeth; Billstedt, Eva; Minnis, Helen; Gillberg, Christopher
Titel	Vitamin D and Autism: Clinical Review
Quelle	In: Research in Developmental Disabilities: A Multidisciplinary Journal, 33 (2012) 5, S.1541-1550 (10 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0891-4222
DOI	10.1016/j.ridd.2012.02.015
Schlagwörter	Autism; Pregnancy; Pathology; Genetics; Biology; Nutrition; Pervasive Developmental Disorders; At Risk Persons; Environmental Influences; Literature Reviews; Etiology + Suchen Sie Ihr Suchwort? Autismus; Schwangerschaft; Pathologie; Humangenetik; Biologie; Ernährung; Risikogruppe; Environmental influence; Umwelteinfluss; Ätiologie
Abstract	Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with multiple genetic and environmental risk factors. The interplay between genetic and environmental factors has become the subject of intensified research in the last several years. Vitamin D deficiency has recently been proposed as a possible environmental risk factor for ASD. Objective: The aim of the current paper is to systematically review the research regarding the possible connection between ASD and vitamin D, and to provide a narrative review of the literature regarding the role of vitamin D in various biological processes in order to generate hypotheses for future research. Results: Systematic data obtained by different research groups provide some, albeit very limited, support for the possible role of vitamin D deficiency in the pathogenesis of ASD. There are two main areas of involvement of vitamin D in the human body that could potentially have direct impact on the development of ASD: (1) the brain (its homeostasis, immune system and neurodevelopment) and (2) gene regulation. Conclusion: Vitamin D deficiency--either during pregnancy or early childhood--may be an environmental trigger for ASD in individuals genetically predisposed for the broad phenotype of autism. On the basis of the results of the present review, we argue for the recognition of this possibly important role of vitamin D in ASD, and for urgent research in the field. (Contains 3 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10