Long-Term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, Are Related to Uncinate Fasciculus Integrity in Autism

Autor/inn/en	Pardini, Matteo; Elia, Maurizio; Garaci, Francesco G.; Guida, Silvia; Coniglione, Filadelfo; Krueger, Frank; Benassi, Francesca; Gialloreti, Leonardo Emberti
Titel	Long-Term Cognitive and Behavioral Therapies, Combined with Augmentative Communication, Are Related to Uncinate Fasciculus Integrity in Autism
Quelle	In: Journal of Autism and Developmental Disorders, 42 (2012) 4, S.585-592 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-011-1281-2
Schlagwörter	Augmentative and Alternative Communication; Autism; Integrity; Therapy; Cognitive Restructuring; Behavior Modification; Brain; Physical Therapy; Diagnostic Tests; Correlation; Outcomes of Treatment; Intelligence Quotient; Age Differences; Symptoms (Individual Disorders); Severity (of Disability); Compliance (Psychology); Rehabilitation + Suchen Sie Ihr Suchwort? Autismus; Integrität; Therapie; Behaviour modification; Verhaltensänderung; Gehirn; Physiotherapie; Diagnostic test; Diagnostischer Test; Korrelation; Intelligenzquotient; Age; Difference; Age difference; Altersunterschied; Psychiatrische Symptomatik; Schweregrad
Abstract	Recent evidence points to white-matter abnormalities as a key factor in autism physiopathology. Using Diffusion Tensor Imaging, we studied white-matter structural properties in a convenience sample of twenty-two subjects with low-functioning autism exposed to long-term augmentative and alternative communication, combined with sessions of cognitive and behavioral therapy. Uncinate fasciculus structural properties correlated significantly with therapy length and early onset, as well as to clinical outcome, independently from IQ, age or symptoms severity at therapy onset. Moreover, adherence to therapy was linked with better clinical outcome and uncinate fasciculus structural integrity. The results point to the capability of a long-term rehabilitation of subjects with low-functioning autism to produce white-matter structural modifications, which could thus play a role in the rehabilitative outcome. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10