Reward-Related Decision-Making in Pediatric Major Depressive Disorder: An fMRI Study

Autor/inn/en	Forbes, Erika E.; Christopher May, J.; Siegle, Greg J.; Ladouceur, Cecile D.; Ryan, Neal D.; Carter, Cameron S.; Birmaher, Boris; Axelson, David A.; Dahl, Ronald E.
Titel	Reward-Related Decision-Making in Pediatric Major Depressive Disorder: An fMRI Study
Quelle	In: Journal of Child Psychology and Psychiatry, 47 (2006) 10, S.1031-1040 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2006.01673.x
Schlagwörter	Anxiety Disorders; Brain; Rewards; Probability; Depression (Psychology); Decision Making; Children; Diagnostic Tests; Affective Behavior; Responses; Neurological Organization; Adolescents + Suchen Sie Ihr Suchwort? Gehirn; Reward; Belohnung; Wahrscheinlichkeitsrechnung; Wahrscheinlichkeitstheorie; Decision-making; Entscheidungsfindung; Child; Kind; Kinder; Diagnostic test; Diagnostischer Test; Affective disturbance; Active behaviour; Affektive Störung; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher
Abstract	Background: Although reward processing is considered an important part of affective functioning, few studies have investigated reward-related decisions or responses in young people with affective disorders. Depression is postulated to involve decreased activity in reward-related affective systems. Methods: Using functional magnetic resonance imaging (fMRI), we examined behavioral and neural responses to reward in young people with depressive disorders using a reward decision-making task. The task involved choices about possible rewards involving varying magnitude and probability of reward. The study design allowed the separation of decision/anticipation and outcome phases of reward processing. Participants were 9-17 years old and had diagnoses of major depressive disorder (MDD), anxiety disorders, or no history of psychiatric disorder. Results: Participants with MDD exhibited less neural response than control participants in reward-related brain areas during both phases of the task. Group differences did not appear to be a function of anxiety. Depressive and anxiety symptoms were associated with activation in reward-related brain areas. Conclusions: Results suggest that depression involves altered reward processing and underscore the need for further investigation of relations among development, affective disorders, and reward processing. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10