A Mechanism for the Formation of Hippocampal Neuronal Firing Patterns that Represent What Happens Where

Autor/inn/en	Tort, Adriano B. L.; Komorowski, Robert; Kopell, Nancy; Eichenbaum, Howard
Titel	A Mechanism for the Formation of Hippocampal Neuronal Firing Patterns that Represent What Happens Where
Quelle	In: Learning & Memory, 18 (2011) 11, S.718-727 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.2307711
Schlagwörter	Animals; Brain Hemisphere Functions; Context Effect; Correlation; Memory; Associative Learning; Task Analysis; Cytology; Responses; Animal Behavior; Stimuli; Rewards + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Korrelation; Gedächtnis; Aufgabenanalyse; Zytologie; Tierverhalten; Anreizsystem; Reward; Belohnung
Abstract	The association of specific events with the context in which they occur is a fundamental feature of episodic memory. However, the underlying network mechanisms generating what-where associations are poorly understood. Recently we reported that some hippocampal principal neurons develop representations of specific events occurring in particular locations (item-position cells). Here, we investigate the emergence of item-position selectivity as rats learn new associations for reward and find that before the animal's performance rises above chance in the task, neurons that will later become item-position cells have a strong selective bias toward one of two behavioral responses, which the animal will subsequently make to that stimulus. This response bias results in an asymmetry of neural activity on correct and error trials that could drive the emergence of particular item specificities based on a simple reward-driven synaptic plasticity mechanism. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10