Medial Prefrontal Cortex Activation Facilitates Re-Extinction of Fear in Rats

Autor/inn/en	Chang, Chun-hui; Maren, Stephen
Titel	Medial Prefrontal Cortex Activation Facilitates Re-Extinction of Fear in Rats
Quelle	In: Learning & Memory, 18 (2011) 4, S.221-225 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.2070111
Schlagwörter	Fear; Brain Hemisphere Functions; Animals; Drug Use; Conditioning; Auditory Stimuli; Behavior Change; Learning Processes + Suchen Sie Ihr Suchwort? Furcht; Animal; Tier; Tiere; Drug consumption; Substance abuse; Drogenkonsum; Auditive Stimulation; Learning process; Lernprozess
Abstract	It has been suggested that reduced infralimbic (IL) cortical activity contributes to impairments of fear extinction. We therefore explored whether pharmacological activation of the IL would facilitate extinction under conditions it normally fails (i.e., immediate extinction). Rats received auditory fear conditioning 1 h before extinction training. Immediately prior to extinction, rats received microinfusions into the IL of the GABAA receptor antagonist, picrotoxin, or the NMDA receptor partial agonist, D-cycloserine. Although neither drug facilitated extinction, they both facilitated the subsequent re-extinction of fear when animals were trained in a drug-free state, suggesting that activating the IL primes behavioral extinction. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10