A Single Brief Burst Induces GluR1-Dependent Associative Short-Term Potentiation: A Potential Mechanism for Short-Term Memory

Autor/inn/en	Erickson, Martha A.; Maramara, Lauren A.; Lisman, John
Titel	A Single Brief Burst Induces GluR1-Dependent Associative Short-Term Potentiation: A Potential Mechanism for Short-Term Memory
Quelle	In: Journal of Cognitive Neuroscience, 22 (2010) 11, S.2530-2540 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0898-929X
DOI	10.1162/jocn.2009.21375
Schlagwörter	Animals; Stimuli; Short Term Memory; Conditioning; Metabolism; Behavioral Science Research; Cognitive Processes + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Anreizsystem; Kurzzeitgedächtnis; Stoffwechsel; Cognitive process; Kognitiver Prozess
Abstract	Recent work showed that short-term memory (STM) is selectively reduced in GluR1 knockout mice. This raises the possibility that a form of synaptic modification dependent on GluR1 might underlie STM. Studies of synaptic plasticity have shown that stimuli too weak to induce long-term potentiation induce short-term potentiation (STP), a phenomenon that has received little attention. Here we examined several properties of STP and tested the dependence of STP on GluR1. The minimal requirement for inducing STP was examined using a test pathway and a conditioning pathway. Several closely spaced stimuli in the test pathway, forming a single brief burst, were sufficient to induce STP. Thus, STP is likely to be induced by the similar bursts that occur in vivo. STP induction is associative in nature and dependent on the NMDAR. STP decays with two components, a fast component (1.6 plus or minus 0.26 min) and a slower one (19 plus or minus 6.6 min). To test the role of GluR1 in STP, experiments were conducted on GluR1 knockout mice. We found that STP was greatly reduced. These results, taken together with the behavioral work of D. Sanderson et al. [Sanderson, D., Good, M. A., Skelton, K., Sprengel, R., Seeburg, P. H., Nicholas, J., et al. "Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model." "Learning and Memory," 2009], provide genetic evidence that STP is a likely mechanism of STM. (As Provided).
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Update	2017/4/10