Kappa Opioid Receptors Mediate where Fear Is Expressed Following Extinction Training

Autor/inn/en	Cole, Sindy; Richardson, Rick; McNally, Gavan P.
Titel	Kappa Opioid Receptors Mediate where Fear Is Expressed Following Extinction Training
Quelle	In: Learning & Memory, 18 (2011) 2, S.88-95 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.2049511
Schlagwörter	Stimuli; Conditioning; Fear; Brain Hemisphere Functions; Animals; Drug Use; Inhibition; Cognitive Processes + Suchen Sie Ihr Suchwort? Anreizsystem; Furcht; Animal; Tier; Tiere; Drug consumption; Substance abuse; Drogenkonsum; Hemmung; Cognitive process; Kognitiver Prozess
Abstract	Six experiments used a within-subjects renewal design to examine the involvement of kappa opioid receptors (KORs) in regulating the expression and recovery of extinguished fear. Rats were trained to fear a tone conditioned stimulus (CS) via pairings with foot shock in a distinctive context (A). This was followed by extinction training of the CS in a second context (B). Finally, all rats were tested for fear to the tone in the extinction context (ABB) and the training (ABA) or a novel (ABC) context. Intracerebroventricular (ICV) infusion of the KOR antagonist nor-binaltorphimine dihydrochloride (nor-BNI) dose-dependently prevented ABA renewal of fear, but had no effect on the expression of ABC renewal, the expression of extinction, or the expression of nonextinguished fear. Conversely, pretest infusion of the KOR agonist U50,488 hydrochloride (U50,488) selectively facilitated the expression of ABA renewal and had no effect on the expression of extinction. Pretest infusion of nor-BNI had no effect on the expression of context-specific latent inhibition. Collectively, these results suggest that KORs gate the expression of fear following extinction training and may comprise a critical neuropeptide component of the circuitry underlying context-dependent expression of fear. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10