Perinatal Risk Factors Interacting with Catechol O-Methyltransferase and the Serotonin Transporter Gene Predict ASD Symptoms in Children with ADHD

Autor/inn/en	Nijmeijer, Judith S.; Hartman, Catharina A.; Rommelse, Nanda N. J.; Altink, Marieke E.; Buschgens, Cathelijne J. M.; Fliers, Ellen A.; Franke, Barbara; Minderaa, Ruud B.; Ormel, Johan; Sergeant, Joseph A.; Verhulst, Frank C.; Buitelaar, Jan K.; Hoekstra, Pieter J.
Titel	Perinatal Risk Factors Interacting with Catechol O-Methyltransferase and the Serotonin Transporter Gene Predict ASD Symptoms in Children with ADHD
Quelle	In: Journal of Child Psychology and Psychiatry, 51 (2010) 11, S.1242-1250 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2010.02277.x
Schlagwörter	Body Weight; Social Behavior; Smoking; Autism; Pervasive Developmental Disorders; Attention Deficit Disorders; Prenatal Influences; Attention Deficit Hyperactivity Disorder; Pregnancy; Risk; Genetics; Symptoms (Individual Disorders); Perinatal Influences; Foreign Countries; Regression (Statistics); Surveys; Questionnaires; Netherlands + Suchen Sie Ihr Suchwort? Körpergewicht; Social behaviour; Soziales Verhalten; Rauchen; Autismus; Attention deficit hyperactivity disorder; ADHS; Aufmerksamkeits-Defizit-Hyperaktivitäts-Störung; Aufmerksamkeitsstörung; Pränataler Einfluss; Schwangerschaft; Risiko; Humangenetik; Psychiatrische Symptomatik; Perinatalperiode; Ausland; Regression; Regressionsanalyse; Survey; Umfrage; Befragung; Fragebogen; Niederlande
Abstract	Background: Symptoms of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) often co-occur. Given the previously found familiality of ASD symptoms in children with ADHD, addressing these symptoms may be useful for genetic association studies, especially for candidate gene findings that have not been consistently replicated for ADHD. Methods: We studied the association of the catechol O-methyltransferase ("COMT") Val158Met polymorphism and the serotonin transporter ("SLC6A4/SERT/5-HTT") 5-HTTLPR insertion/deletion polymorphism with ASD symptoms in children with ADHD, and whether these polymorphisms would interact with pre- and perinatal risk factors, i.e., maternal smoking during pregnancy and low birth weight. Analyses were performed using linear regression in 207 Dutch participants with combined type ADHD of the International Multicenter ADHD Genetics (IMAGE) study, and repeated in an independent ADHD sample (n = 439) selected from the TRacking Adolescents' Individual Lives Survey (TRAILS). Dependent variables were the total and subscale scores of the Children's Social Behavior Questionnaire (CSBQ). Results: No significant main effects of "COMT" Val158Met, 5-HTTLPR, maternal smoking during pregnancy and low birth weight on ASD symptoms were found. However, the "COMT" Val/Val genotype interacted with maternal smoking during pregnancy in increasing stereotyped behavior in the IMAGE sample (p = 0.008); this interaction reached significance in the TRAILS sample after correction for confounders (p = 0.02). In the IMAGE sample, the 5-HTTLPR S/S genotype interacted with maternal smoking during pregnancy, increasing problems in social interaction (p = 0.02), and also interacted with low birth weight, increasing rigid behavior (p = 0.03). Findings for 5-HTTLPR in the TRAILS sample were similar, albeit for related CSBQ subscales. Conclusions: These findings suggest gene-environment interaction effects on ASD symptoms in children with ADHD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10