A Cognitive Endophenotype of Autism in Families with Multiple Incidence

Autor/inn/en	Nyden, Agneta; Hagberg, Bibbi; Gousse, Veronique; Rastam, Maria
Titel	A Cognitive Endophenotype of Autism in Families with Multiple Incidence
Quelle	In: Research in Autism Spectrum Disorders, 5 (2011) 1, S.191-200 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1750-9467
DOI	10.1016/j.rasd.2010.03.010
Schlagwörter	Autism; Pervasive Developmental Disorders; Genetics; Incidence; Family (Sociological Unit); Children; Parents; Siblings; Cognitive Processes; Spatial Ability; Theory of Mind + Suchen Sie Ihr Suchwort? Autismus; Humangenetik; Vorkommen; Familie; Child; Kind; Kinder; Eltern; Sibling; Geschwister; Cognitive process; Kognitiver Prozess; Räumliches Vorstellungsvermögen
Abstract	Twin and family studies have established that there is a strong genetic basis for autism spectrum disorders. To facilitate the identification of susceptibility genes and to study pathways from gene-brain to cognition a more refined endophenotype-based approach may be useful. The purpose of the present study was to examine the neurocognitive endophenotype of autism, in families with multiple incidence autism. Eighty-six members of 18 families containing at least two individuals with autism were neuropsychological assessed. Children with autism, showed weak central coherence, but this "trait" could not be found in their parents nor in non-affected siblings. All family members, including the sibpairs with autism, showed deficits within executive functions, involving planning ability, but normal set-shifting. The sibpairs with autism--but not their other family members--showed significant correlations within two visuo-spatial tasks. Deficits in executive functions (specifically planning ability) appear to characterize the broader endophenotype of autism. Our findings do not confirm the hypotheses of weak central coherence or deficits in theory of mind as part of the broader endophenotype of autism. Deficits in visual scanning may be a feature of the manifest phenotype of autism. (Contains 3 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10