Genetic Etiology in Cases of Recovered and Persistent Stuttering in an Unselected, Longitudinal Sample of Young Twins

Autor/inn/en	Dworzynski, Katharina; Remington, Anna; Rijsdijk, Fruhling; Howell, Peter; Plomin, Robert
Titel	Genetic Etiology in Cases of Recovered and Persistent Stuttering in an Unselected, Longitudinal Sample of Young Twins
Quelle	In: American Journal of Speech-Language Pathology, 16 (2007) 2, S.169-178 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1058-0360
DOI	10.1044/1058-0360(2007/021)
Schlagwörter	Twins; Stuttering; Genetics; Etiology; Age Differences; Children; Evaluation Methods; Classification; Regression (Statistics); Speech Language Pathology; Gender Differences; Longitudinal Studies + Suchen Sie Ihr Suchwort? Twin; Zwilling; Stammer; Stottern; Humangenetik; Ätiologie; Age; Difference; Age difference; Altersunterschied; Child; Kind; Kinder; Classification system; Klassifikation; Klassifikationssystem; Regression; Regressionsanalyse; Geschlechterkonflikt; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung
Abstract	Purpose: The contribution of genetic factors in the persistence of and early recovery from stuttering was assessed. Method: Data from the Twins Early Development Study were employed. Parental reports regarding stuttering were collected at ages 2, 3, 4, and 7 years, and were used to classify speakers into recovered and persistent groups. Of 12,892 children with at least 2 ratings, 950 children had recovered and 135 persisted in their stutter. Results: Logistic regressions showed that the rating at age 2 was not predictive of later stuttering, whereas ratings at ages 3 and 4 were. Concordance rates were consistently higher for monozygotic than for dizygotic twin pairs (with the exception of girls at age 3). At 3, 4, and 7 years, the liability to stuttering was highly heritable (h2 estimates of between 0.58 and 0.66). Heritability for the recovered and persistent groups was also high but did not differ from each other. Conclusion: Stuttering appears to be a disorder that has high heritability and little shared environment effect in early childhood and for recovered and persistent groups of children, by age 7. The clinical implications of the findings are discussed. (Contains 10 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10