Dorsal Hippocampal CREB Is Both Necessary and Sufficient for Spatial Memory

Autor/inn/en	Sekeres, Melanie J.; Neve, Rachael L.; Frankland, Paul W.; Josselyn, Sheena A.
Titel	Dorsal Hippocampal CREB Is Both Necessary and Sufficient for Spatial Memory
Quelle	In: Learning & Memory, 17 (2010) 6, S.280-283 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1785510
Schlagwörter	Animals; Memory; Spatial Ability; Brain; Cognitive Processes + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Gedächtnis; Räumliches Vorstellungsvermögen; Gehirn; Cognitive process; Kognitiver Prozess
Abstract	Although the transcription factor CREB has been widely implicated in memory, whether it is sufficient to produce spatial memory under conditions that do not normally support memory formation in mammals is unknown. We found that locally and acutely increasing CREB levels in the dorsal hippocampus using viral vectors is sufficient to induce robust spatial memory in two conditions that do not normally support spatial memory, weakly trained wild-type (WT) mice and strongly trained mutant mice with a brain-wide disruption of CREB function. Together with previous results, these findings indicate that CREB is both necessary and sufficient for spatial memory formation, and highlight its pivotal role in the hippocampal molecular machinery underlying the formation of spatial memory. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10