Deficits in Sensory-Specific Devaluation Task Performance Following Genetic Deletions of Cannabinoid (CB1) Receptor

Autor/inn/en	Crombag, Hans S.; Johnson, Alexander W.; Zimmer, Anne M.; Zimmer, Andreas; Holland, Peter C.
Titel	Deficits in Sensory-Specific Devaluation Task Performance Following Genetic Deletions of Cannabinoid (CB1) Receptor
Quelle	In: Learning & Memory, 17 (2010) 1, S.18-22 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1610510
Schlagwörter	Animal Behavior; Animals; Brain; Evaluation Methods; Food; Classical Conditioning; Experiential Learning + Suchen Sie Ihr Suchwort? Tierverhalten; Animal; Tier; Tiere; Gehirn; Lebensmittel; Experiental learning; Erfahrungsorientiertes Lernen
Abstract	Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation. These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10