Cerebellum, Language, and Cognition in Autism and Specific Language Impairment

Autor/inn/en	Hodge, Steven M.; Makris, Nikos; Kennedy, David N.; Caviness, Verne S., Jr.; Howard, James; McGrath, Lauren; Steele, Shelly; Frazier, Jean A.; Tager-Flusberg, Helen; Harris, Gordon J.
Titel	Cerebellum, Language, and Cognition in Autism and Specific Language Impairment
Quelle	In: Journal of Autism and Developmental Disorders, 40 (2010) 3, S.300-316 (17 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-009-0872-7
Schlagwörter	Autism; Language Impairments; Performance Tests; Short Term Memory; Brain Hemisphere Functions; Cognitive Ability; Neurological Impairments; Diagnostic Tests; Males; Children; Early Adolescents; Comparative Analysis; Cognitive Processes; Attention + Suchen Sie Ihr Suchwort? Autismus; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Leistungsbeurteilung; Leistungsermittlung; Leistungsmessung; Leistungsüberprüfung; Kurzzeitgedächtnis; Denkfähigkeit; Neurodegenerative Erkrankung; Diagnostic test; Diagnostischer Test; Male; Männliches Geschlecht; Child; Kind; Kinder; Cognitive process; Kognitiver Prozess; Aufmerksamkeit
Abstract	We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6-13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I-V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10