Neuropsychological Profile of Children with Subcortical Band Heterotopia

Autor/inn/en	Spencer-Smith, Megan; Leventer, Richard; Jacobs, Rani; De Luca, Cinzia; Anderson, Vicki
Titel	Neuropsychological Profile of Children with Subcortical Band Heterotopia
Quelle	In: Developmental Medicine & Child Neurology, 51 (2009) 11, S.909-916 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0012-1622
DOI	10.1111/j.1469-8749.2009.03309.x
Schlagwörter	Intelligence Quotient; Genetics; Short Term Memory; Cognitive Processes; Arithmetic; Brain; Neurological Impairments; Neurological Organization; Children; Adolescents; Cognitive Ability; Attention; Academic Achievement; Reading Achievement; Mathematics Achievement; Spelling; Questionnaires; Interpersonal Competence; Parent Attitudes; Behavior Problems; Diagnostic Tests; Seizures; Mental Retardation; Child Development + Suchen Sie Ihr Suchwort? Intelligenzquotient; Humangenetik; Kurzzeitgedächtnis; Cognitive process; Kognitiver Prozess; Addition; Arithmetik; Arithmetikunterricht; Rechnen; Gehirn; Neurodegenerative Erkrankung; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Denkfähigkeit; Aufmerksamkeit; Schulleistung; Leseleistung; Mathmatics sikills; Mathmatics achievement; Mathematical ability; Mathematische Kompetenz; Schreibweise; Fragebogen; Interpersonale Kompetenz; Elternverhalten; Diagnostic test; Diagnostischer Test; Anfallsleiden; Geistige Behinderung; Kindesentwicklung
Abstract	Aim: Subcortical band heterotopia (SBH) or "double cortex" is a malformation of cortical development resulting from impaired neuronal migration. So far, research has focused on the neurological, neuroimaging, and genetic correlates of SBH. More recently, clinical reports and small sample studies have documented neuropsychological dysfunction in patients with this malformation. This study aimed to characterize further the phenotype of patients with SBH by describing the neuropsychological profiles of children. Method: Seven children (six females) aged 4 to 15 years were assessed for cognitive functioning (intellectual ability, processing speed, attention, working memory) and academic achievement (reading, spelling, arithmetic). Parents completed questionnaires examining their child's social skills and problem behaviours. Magnetic resonance images (MRI) conducted for routine clinical follow-up were coded by a paediatric neurologist. Genetic and seizure history were obtained from medical records. Results: There was variation in the neurological, neuroimaging, and genetic presentation of children in the sample. Impairments were observed in all areas of neuropsychological functioning examined. Intellectual ability was generally within the "extremely low" range (full-scale IQ 44-74; performance IQ 45-72; verbal IQ 57-80). Generalized impairments in cognitive skills were typical, with severe impairments (scores greater than 2SD below the test mean) reported in processing speed, working memory, and arithmetic. Impairments in academic, social, and behavioural functioning were less generalized. No clear relationship between neuroimaging and neuropsychological impairments was found. Interpretation: Children with SBH demonstrate cognitive, academic, social, and behavioural problems, with the greatest difficulties in processing speed and complex cognitive skills. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10