Stimulus-Outcome Learnability Differentially Activates Anterior Cingulate and Hippocampus at Feedback Processing

Autor/in	Rodriguez, Paul F.
Titel	Stimulus-Outcome Learnability Differentially Activates Anterior Cingulate and Hippocampus at Feedback Processing
Quelle	In: Learning & Memory, 16 (2009) 5, S.324-331 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1191609
Schlagwörter	Feedback (Response); Prediction; Memory; Probability; Associative Learning; Reinforcement; Stimuli; Models; Brain; Association (Psychology); Statistical Analysis; Neurology + Suchen Sie Ihr Suchwort? Vorhersage; Gedächtnis; Wahrscheinlichkeitsrechnung; Wahrscheinlichkeitstheorie; Positive Verstärkung; Anreizsystem; Analogiemodell; Gehirn; Assoziation; Statistische Analyse; Neurologie
Abstract	Memory systems are known to be influenced by feedback and error processing, but it is not well known what aspects of outcome contingencies are related to different memory systems. Here we use the Rescorla-Wagner model to estimate prediction errors in an fMRI study of stimulus-outcome association learning. The conditional probabilities of outcomes for a given stimulus are manipulated so that associations are either learnable or unlearnable (pseudorandom). The delay between stimulus and outcome is jittered so that we can separately compare activity for either stimulus processing or feedback processing. We find that hippocampus and anterior cingulate are differentially active primarily at feedback processing: Learnable associations are correlated with significantly more hippocampal activity and significantly less anterior cingulate activity than unlearnable associations. We also find that positive prediction errors modulate feedback processing in the midbrain for both types of associations. We suggest that learnable associations use more declarative memory, unlearnable associations involve more uncertainty monitoring, and, in both kinds of associations, positive prediction errors provide a reinforcement signal. (Contains 5 tables and 3 figures.) (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10