Association between Therapy Outcome and Right-Hemispheric Activation in Chronic Aphasia

Autor/inn/en	Richter, Maria; Miltner, Wolfgang H. R.; Straube, Thomas
Titel	Association between Therapy Outcome and Right-Hemispheric Activation in Chronic Aphasia
Quelle	In: Brain, 131 (2008) 5, S.1391-1401 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0006-8950
DOI	10.1093/brain/awn043
Schlagwörter	Brain Hemisphere Functions; Aphasia; Patients; Language Processing; Therapy; Outcomes of Treatment; Correlation + Suchen Sie Ihr Suchwort? Expressive Aphasie; Aphasie; Patient; Sprachverarbeitung; Therapie; Korrelation
Abstract	The role of the right hemisphere for language processing and successful therapeutic interventions in aphasic patients is a matter of debate. This study explored brain activation in right-hemispheric areas and left-hemispheric perilesional areas in response to language tasks in chronic non-fluent aphasic patients before and after constraint-induced aphasia therapy (CIAT). In particular, we analysed the relation between brain responses and therapy outcome. Using functional magnetic resonance imaging (fMRI), brain activation was measured during word-reading (REA) and word-stem completion (COM) in 16 chronic non-fluent aphasic and 8 healthy subjects. Before therapy, activation in right inferior frontal gyrus/insula (IFG/IC) was stronger in aphasics compared to controls during REA and in precentral gyrus (PCG) during COM. Therapeutic intervention "per se" did not change brain activation for either task across all aphasic subjects. However, therapeutic success correlated with a relative decrease of activation in right-hemispheric areas, including the IFG/IC. Most importantly, initial activation in right IFG/IC and other right-hemispheric areas correlated positively with subsequent therapy success. Thus, right-hemispheric activation prior to aphasia therapy strongly predicts therapeutic success, suggesting that brain activation in chronic aphasia indicates the patients' potential for further language improvement. (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10