Estrogen Abolishes Latent Inhibition in Ovariectomized Female Rats

Autor/inn/en	Nofrey, Barbara S.; Ben-Shahar, Osnat M.; Brake, Wayne G.
Titel	Estrogen Abolishes Latent Inhibition in Ovariectomized Female Rats
Quelle	In: Brain and Cognition, 66 (2008) 2, S.156-160 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2007.06.003
Schlagwörter	Stimuli; Females; Pregnancy; Inhibition; Animals; Attention; Cognitive Processes; Metabolism + Suchen Sie Ihr Suchwort? Anreizsystem; Weibliches Geschlecht; Schwangerschaft; Hemmung; Animal; Tier; Tiere; Aufmerksamkeit; Cognitive process; Kognitiver Prozess; Stoffwechsel
Abstract	Estrogen is frequently prescribed as a method of birth control and as hormone replacement therapy for post-menopausal women with varied effects on cognition. Here the effects of estrogen on attention were examined using the latent inhibition (LI) behavioral paradigm. Ovariectomized (OVX) female rats were given either estrogen benzoate (EB, 10 or 100[mu]g/ml/kg; SC) or sesame oil vehicle. Males and OVX females receiving vehicle displayed normal LI. In contrast, LI was abolished in OVX females receiving EB. The lack of LI in OVX females receiving EB was a result of low suppression ratios, reflecting strong conditioning between the tone and the shock in these subjects even if they were pre-exposed to the tone. Thus, estrogen impaired the ability of OVX females to ignore irrelevant stimuli. Since different cognitive tasks vary in their required ability to ignore irrelevant stimuli, these results may account for some of the variations in the current literature on estrogen and cognition. (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10