Literaturnachweis - Detailanzeige
Autor/inn/en | Hoffman, Alexander F.; Oz, Murat; Yang, Ruiqin; Lichtman, Aron H.; Lupica, Carl R. |
---|---|
Titel | Opposing Actions of Chronic[Deta][superscript 9] Tetrahydrocannabinol and Cannabinoid Antagonists on Hippocampal Long-Term Potentiation |
Quelle | In: Learning & Memory, 14 (2007) 1-2, S.63-74 (12 Seiten)
PDF als Volltext |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 1072-0502 |
Schlagwörter | Marijuana; Neurological Impairments; Drug Abuse; Spectroscopy; Cytology; Anatomy; Brain Hemisphere Functions; Molecular Biology; Science Experiments; Scientific Methodology; Animals; Long Term Memory; Mnemonics |
Abstract | Memory deficits produced by marijuana arise partly via interaction of the psychoactive component, [Deta][superscript 9]-tetrahydrocannabinol ([Deta][superscript 9]-THC), with cannabinoid receptors in the hippocampus. Although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (LTP), a potential substrate for learning and memory, the consequences of prolonged exposure to [Deta][superscript 9]-THC for hippocampal function are poorly understood. Rats were injected with [Deta][superscript 9]-THC (10 mg/kg, i.p., q.d.) for 1, 3, or 7 d, and electrophysiological recordings were performed in hippocampal slices 1d after the final injection. At this time, [Deta][superscript 9]-THC was undetectable in hippocampus using liquid chromatography-mass spectrometry (LC-MS). Hippocampal LTP generated using high-frequency (HFS) or theta burst stimulation was not observed in brain slices from the 7-d [Deta][superscript 9]-THC-treated animals. [Deta][superscript 9]-THC also blocked HFS-LTP after 3 d, but not 1 d of treatment. The complete blockade of LTP persisted for 3 d after the last [Deta][superscript 9]-THC injection, and full reversal of the LTP deficit was not observed up to 14 d following [Deta][superscript 9]-THC withdrawal. The cannabinoid antagonist AM251 (2 mg/kg), administered before each [Deta][superscript 9]-THC injection prevented the blockade of LTP, and 7-d treatment with AM251 alone significantly increased the level of LTP. Chronic [Deta][superscript 9]-THC also produced tolerance to the inhibition of synaptic GABA, but not glutamate release by the agonist WIN55,212-2. These data define consequences of repeated [Deta][superscript 9]-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use. (Author). |
Anmerkungen | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2017/4/10 |