Reconsolidation after Remembering an Odor-Reward Association Requires NMDA Receptors

Autor/inn/en	Torras-Garcia, Meritxell; Tronel, Sophie; Sara, Susan J.; Lelong, Julien
Titel	Reconsolidation after Remembering an Odor-Reward Association Requires NMDA Receptors
Quelle	In: Learning & Memory, 12 (2005) 1, S.18-22 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Mnemonics; Role Perception; Memory; Memorization; Association (Psychology); Context Effect; Neurological Impairments; Conditioning; Drug Therapy; Sensory Aids; Scientific Methodology; Science Experiments; Discrimination Learning + Suchen Sie Ihr Suchwort? Mnemotechnik; Role conception; Rollenverständnis; Gedächtnis; Gedächtnistraining; Assoziation; Neurodegenerative Erkrankung; Sinnesreiz; Lernen; Lernprozess
Abstract	A rapidly learned odor discrimination task based on spontaneous foraging behavior of the rat was used to evaluate the role of N-methyl-D-aspartate (NMDA) receptors (NMDARs) in ongoing memory consolidation. Rats were trained in a single session to discriminate among three odors, one of which was associated with palatable food reward. Previous experiments showed that the NMDAR antagonist DL-APV induced amnesia for this task when injected immediately after training. In the present study, memory was reactivated 24 h after training by exposure to the rewarded odor within the experimental context after which rats received an intracerebroventricular injection of APV. Combined reactivation-drug treatment induced profound amnesia when tested 48 h later. Animals receiving drug alone, in absence of reactivation, showed perfect retention. It is concluded that NMDARs support a consolidation process taking place after memory reactivation. (Contains 2 figures.) (Author).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10