Differential Involvement of the Central Amygdala in Appetitive versus Aversive Learning

Autor/inn/en	Lipp, Hans-Peter; Kaczmarek, Leszek; Werka, Tomasz; Knapska, Ewelina; Walasek, Grazyna; Nikolaev, Evgeni; Neuhausser-Wespy, Frieder
Titel	Differential Involvement of the Central Amygdala in Appetitive versus Aversive Learning
Quelle	In: Learning & Memory, 13 (2006) 2, S.192-200 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.54706
Schlagwörter	Conditioning; Acoustics; Laboratory Equipment; Neurological Organization; Auditory Stimuli; Reinforcement; Learning Processes; Nonverbal Learning; Memory; Punishment; Behavioral Science Research; Brain; Negative Reinforcement; Animals + Suchen Sie Ihr Suchwort? Akustik; Laborausstattung; Auditive Stimulation; Positive Verstärkung; Learning process; Lernprozess; Gedächtnis; Bestrafung; Gehirn; Negative Verstärkung; Animal; Tier; Tiere
Abstract	Understanding the function of the distinct amygdaloid nuclei in learning comprises a major challenge. In the two studies described herein, we used c-Fos immunolabeling to compare the engagement of various nuclei of the amygdala in appetitive and aversive instrumental training procedures. In the first experiment, rats that had already acquired a bar-pressing response to a partial food reinforcement were further trained to learn that an acoustic stimulus signaled either continuous food reinforcement (appetitive training) or a footshock (aversive training). The first training session of the presentation of the acoustic stimulus resulted in significant increases of c-Fos immunolabeling throughout the amygdala; however, the pattern of activation of the nuclei of the amygdala differed according to the valence of motivation. The medial part of the central amygdala (CE) responded, surprisingly, to the appetitive conditioning selectively. The second experiment was designed to extend the aversive versus appetitive conditioning to mice, trained either for place preference or place avoidance in an automated learning system (INTELLICAGE). Again, much more intense c-Fos expression was observed in the medial part of the CE after the appetitive training as compared to the aversive training. These data, obtained in two species and by means of novel experimental approaches balancing appetitive versus aversive conditioning, support the hypothesis that the central nucleus of the amygdala is particularly involved in appetitively motivated learning processes. (Contains 2 tables and 6 figures.) (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10