Inactivation of the Ventral Tegmental Area Abolished the General Excitatory Influence of Pavlovian Cues on Instrumental Performance

Autor/inn/en	Murschall, Anja; Hauber, Wolfgang
Titel	Inactivation of the Ventral Tegmental Area Abolished the General Excitatory Influence of Pavlovian Cues on Instrumental Performance
Quelle	In: Learning & Memory, 13 (2006) 2, S.123-126 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.127106
Schlagwörter	Auditory Stimuli; Neurological Organization; Behavioral Science Research; Animals; Data Analysis; Nonverbal Learning; Neurological Impairments; Brain; Auditory Training; Cues; Classical Conditioning + Suchen Sie Ihr Suchwort? Auditive Stimulation; Animal; Tier; Tiere; Auswertung; Neurodegenerative Erkrankung; Gehirn; Belgien; Stichwort
Abstract	Pavlovian stimuli can markedly elevate instrumental responding, an effect known as Pavlovian-instrumental transfer (PIT). As the role of the ventral tegmental area (VTA) in PIT is yet unknown, we examined the effects of transient VTA inactivation by direct microinjections of a mixture of the GABA[subscript A] and GABA[subscript B] receptor agonists, muscimol and baclofen. Results reveal that PIT, i.e., the increase in instrumental responding during presentation of a Pavlovian stimulus, was abolished by intra-VTA microinjections of muscimol/baclofen. These data provide the first evidence that the VTA mediates Pavlovian influences on instrumental behavior. (Contains 2 figures.) (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10