Literaturnachweis - Detailanzeige
Autor/inn/en | Panahi, Yasin; Salasar Moghaddam, Fahimeh; Babaei, Khadijeh; Eftekhar, Mohammad; Shervin Badv, Reza; Eskandari, Mohammad Reza; Vafaee-Shahi, Mohammad; Pezeshk, Hamid; Pedram, Mehrdad |
---|---|
Titel | Sexual Dimorphism in Telomere Length in Childhood Autism |
Quelle | In: Journal of Autism and Developmental Disorders, 53 (2023) 5, S.2050-2061 (12 Seiten)
PDF als Volltext |
Zusatzinformation | ORCID (Panahi, Yasin) ORCID (Salasar Moghaddam, Fahimeh) ORCID (Eskandari, Mohammad Reza) ORCID (Pedram, Mehrdad) |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 0162-3257 |
DOI | 10.1007/s10803-022-05486-2 |
Schlagwörter | Autism Spectrum Disorders; Gender Differences; Symptoms (Individual Disorders); Children; Physiology; Incidence; Etiology |
Abstract | Autism spectrum disorders (ASD) are strikingly more prevalent in males, but the molecular mechanisms responsible for ASD sex-differential risk are poorly understood. Abnormally shorter telomeres have been associated with autism. Examination of relative telomere lengths (RTL) among non-syndromic male (N = 14) and female (N = 10) children with autism revealed that only autistic male children had significantly shorter RTL than typically-developing controls (N = 24) and paired siblings (N = 10). While average RTL of autistic girls did not differ significantly from controls, it was substantially longer than autistic boys. Our findings indicate a sexually-dimorphic pattern of RTL in childhood autism and could have important implications for RTL as a potential biomarker and the role/s of telomeres in the molecular mechanisms responsible for ASD sex-biased prevalence and etiology. (As Provided). |
Anmerkungen | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2024/1/01 |