Major Gender Differences in Relations between Life Stressor Frequency and Gray Matter in Adolescence and Emerging Adulthood

Autor/inn/en	Fassett-Carman, Alyssa N.; Smolker, Harry; Hankin, Benjamin L.; Snyder, Hannah R.; Banich, Marie T.
Titel	Major Gender Differences in Relations between Life Stressor Frequency and Gray Matter in Adolescence and Emerging Adulthood
Quelle	In: Developmental Psychology, 59 (2023) 4, S.621-636 (16 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Fassett-Carman, Alyssa N.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0012-1649
DOI	10.1037/dev0001489
Schlagwörter	Brain; Cognitive Development; Brain Hemisphere Functions; Gender Differences; Anxiety; Stress Variables; Adolescents; Young Adults; Colorado (Denver) + Suchen Sie Ihr Suchwort? Gehirn; Kognitive Entwicklung; Geschlechterkonflikt; Angst; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Young adult; Junger Erwachsener
Abstract	Adolescence and emerging adulthood is likely a sensitive period for the neural effects of stress due to increasing life stress, onset of stress-related disorders, and continued gray matter (GM) development. In adults, stress is associated with GM differences in the medial prefrontal cortex (mPFC), hippocampus, and amygdala, but little is known about these relations, and whether they differ by gender, during adolescence and emerging adulthood. Further, it is unknown whether dependent (self-generated) and independent (fateful) stressors have distinct associations with GM, as each have distinct relations with internalizing psychopathology. We tested relations between recent dependent and independent stressor frequency (ALEQ-R) and GM structure using MRI in a priori regions of interest (mPFC, amygdala, and hippocampus) and across the cortex in youth from the Denver/Boulder metro area ages 14-22 (N = 144). Across both genders, no effects passed multiple comparison correction (FDR q > 0.05). However, there were significant differences between male and female youth (FDR q < 0.05), with opposite relations between dependent stressor frequency and cortical GM thickness in the salience network and emotion regulation regions and with surface area in default mode network regions. These results motivate future investigations of gender differences in neural mechanisms of stress generation and reactivity. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01