Characterizing Sleep Problems in 16p11.2 Deletion and Duplication

Autor/inn/en	Kamara, Dana; De Boeck, Paul; Lecavalier, Luc; Neuhaus, Emily; Beauchaine, Theodore P.
Titel	Characterizing Sleep Problems in 16p11.2 Deletion and Duplication
Quelle	In: Journal of Autism and Developmental Disorders, 53 (2023) 4, S.1462-1475 (14 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Kamara, Dana)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-05311-2
Schlagwörter	Youth; Adults; Sleep; Problems; Genetics; Genetic Disorders; Duplication + Suchen Sie Ihr Suchwort? Jugend; Jugendlicher; Jugendalter; Schlaf; Problemsituation; Humangenetik
Abstract	Studies of 16p11.2 copy number variants (CNVs) provide an avenue to identify mechanisms of impairment and develop targeted treatments for individuals with neurodevelopmental disorders. 16p11.2 deletion and duplication phenotypes are currently being ascertained; however, sleep disturbances are minimally described. In this study, we examine sleep disturbance in a well-characterized national sample of 16p11.2 CNVs, the Simons Foundation Autism Research Initiative (SFARI) database of youth and adults (n = 692). Factor analyses and multilevel models of derived sleep questionnaires for youth (n = 345) and adults (n = 347) indicate that 16p11.2 carriers show elevated sleep disturbance relative to community controls. Non-carrier family members also show elevated sleep disturbance. However, sleep duration does not differ between carriers and controls. Further studies of sleep in 16p11.2 are needed. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01