Prenatal Programming of Developmental Trajectories for Obesity Risk and Early Pubertal Timing

Autor/inn/en	Robertson, Olivia C.; Marceau, Kristine; Duncan, Robert J.; Shirtcliff, Elizabeth A.; Leve, Leslie D.; Shaw, Daniel S.; Natsuaki, Misaki; Neiderhiser, Jenae M.; Ganiban, Jody M.
Titel	Prenatal Programming of Developmental Trajectories for Obesity Risk and Early Pubertal Timing
Quelle	In: Developmental Psychology, 58 (2022) 10, S.1817-1831 (15 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Robertson, Olivia C.) ORCID (Marceau, Kristine) ORCID (Duncan, Robert J.) ORCID (Shirtcliff, Elizabeth A.) ORCID (Leve, Leslie D.) ORCID (Natsuaki, Misaki) ORCID (Neiderhiser, Jenae M.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0012-1649
DOI	10.1037/dev0001405
Schlagwörter	Obesity; At Risk Persons; Child Development; Puberty; Prenatal Influences; Young Children; Health; Metabolism; Physiology; Nutrition; Perinatal Influences; Genetics; Preadolescents; Adoption; Individual Characteristics; Socioeconomic Status; Gender Differences; Environmental Influences + Suchen Sie Ihr Suchwort? Adipositas; Risikogruppe; Kindesentwicklung; Pubertät; Pränataler Einfluss; Frühe Kindheit; Gesundheit; Stoffwechsel; Physiologie; Ernährung; Perinatalperiode; Humangenetik; Pre-adolescence; Präadoleszenz; Personality characteristic; Personality traits; Persönlichkeitsmerkmal; Socio-economic status; Sozioökonomischer Status; Geschlechterkonflikt; Environmental influence; Umwelteinfluss
Abstract	The thrifty phenotype and fetal overnutrition hypotheses are two developmental hypotheses that originated from the "developmental origins of health and disease" (DOHaD) perspective. The DOHaD posits that exposures experienced prenatally and early in life may influence health outcomes through altering form and function of internal organs related to metabolic processes. Obesity risk and early pubertal timing might be influenced by similar mechanisms. The thrifty phenotype hypothesis is primarily characterized by experiencing a deprivation of nutrients during gestation paired with an energy rich postnatal environment. The fetal overnutrition hypothesis says that obesity experienced prenatally will be associated with increased lifetime risk of obesity in the offspring. Both hypotheses were tested by examining developmental pathways from genetic and prenatal risk through early growth trajectories (birth to 7 years) to pubertal timing at age 11 years. Participants included 361 children adopted at birth (57% male; 57% non-Hispanic White, 11% Black, 9% Hispanic; adoptive family income Mdn = $70,000-$100,000, birth family income Mdn = <$15,000). Associations between boys' childhood body mass index (BMI) and pubertal timing were confounded by genetics, prenatal risk, and early growth. The thrifty phenotype hypothesis was partially supported for boys' childhood BMI (at ages 4 to 7 years). Both hypotheses were partially supported for girls' childhood BMI but not pubertal timing. A novel Gene x Prenatal Risk interaction showed that genetic risk predicted girls' childhood BMI most strongly at adequate compared with at excessive levels of gestational weight gain. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01