Optogenetic and Thermogenetic Manipulation of Defined Neural Circuits and Behaviors in "Drosophila"

Autor/in	Honda, Takato
Titel	Optogenetic and Thermogenetic Manipulation of Defined Neural Circuits and Behaviors in "Drosophila"
Quelle	In: Learning & Memory, 29 (2022) 4, S.100-109 (10 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Honda, Takato)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Neurological Organization; Animals; Neurosciences; Behavior; Behavioral Science Research + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Neuroscience; Neurowissenschaften; Neurowissenschaft
Abstract	Neural network dynamics underlying flexible animal behaviors remain elusive. The fruit fly "Drosophila" melanogaster is considered an excellent model in behavioral neuroscience because of its simple neuroanatomical architecture and the availability of various genetic methods. Moreover, "Drosophila" larvae's transparent body allows investigators to use optical methods on freely moving animals, broadening research directions. Activating or inhibiting well-defined events in excitable cells with a fine temporal resolution using optogenetics and thermogenetics led to the association of functions of defined neural populations with specific behavioral outputs such as the induction of associative memory. Furthermore, combining optogenetics and thermogenetics with state-of-the-art approaches, including connectome mapping and machine learning-based behavioral quantification, might provide a complete view of the experience- and time-dependent variations of behavioral responses. These methodologies allow further understanding of the functional connections between neural circuits and behaviors such as chemosensory, motivational, courtship, and feeding behaviors and sleep, learning, and memory. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01