Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder

Autor/inn/en	DeCoteau, William E.; Fox, Adam E.
Titel	Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder
Quelle	In: Journal of Autism and Developmental Disorders, 52 (2022) 6, S.2414-2429 (16 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Fox, Adam E.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-05129-y
Schlagwörter	Autism; Pervasive Developmental Disorders; Time Perspective; Animals; Motor Reactions; Intervals; Animal Behavior; Anxiety; Memory; Persistence + Suchen Sie Ihr Suchwort? Autismus; Zeitbezug; Animal; Tier; Tiere; Tierverhalten; Angst; Gedächtnis; Ausdauer
Abstract	Recently it has been proposed that impairments related to autism spectrum disorder (ASD) may reflect a more fundamental disruption in time perception. Here, we examined whether in utero exposure to valproic acid (VPA) can generate specific behavioral deficits related to ASD and time perception. Pups from control and VPA groups were tested using fixed-interval (FI) temporal bisection, peak interval, and intertemporal choice tasks. In addition, the rats were assessed on motor function, perseverative and exploratory behavior, anxiety, and memory. The VPA group displayed a leftward shift in timing functions. VPA rats displayed no deficits on the motor and memory tasks, but were significantly different from controls on measures of perseveration and anxiety. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01