Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism

Autor/inn/en	Aykan, Simge; Puglia, Meghan H.; Kalaycioglu, Canan; Pelphrey, Kevin A.; Tuncali, Timur; Nalçaci, Erhan
Titel	Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism
Quelle	In: Journal of Autism and Developmental Disorders, 52 (2022) 1, S.61-72 (12 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Aykan, Simge)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-021-04924-x
Schlagwörter	Brain Hemisphere Functions; Autism; Genetics; Symptoms (Individual Disorders); Measures (Individuals); Cognitive Processes; Eye Movements + Suchen Sie Ihr Suchwort? Autismus; Humangenetik; Psychiatrische Symptomatik; Messdaten; Cognitive process; Kognitiver Prozess; Augenbewegung
Abstract	Our aim was to use theta coherence as a quantitative trait to investigate the relation of the polymorphisms in "NKCC1" (rs3087889) and "KCC2" (rs9074) channel protein genes to autistic traits (AQ) in neurotypicals. Coherence values for candidate connection regions were calculated from eyes-closed resting EEGs in two independent groups. Hypersynchrony within the right anterior region was related to AQ in both groups (p < 0.05), and variability in this hypersynchrony was related to the rs9074 polymorphism in the total group (p < 0.05). In conclusion, theta hypersynchrony within the right anterior region during eyes-closed rest can be considered a quantitative measure for autistic traits. Replicating our findings in two independent populations with different backgrounds strengthens the validity of the current study. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01