Developmental Emergence of Persistent Memory for Contextual and Auditory Fear in Mice

Autor/inn/en	Samifanni, Rojina; Zhao, Mudi; Cruz-Sanchez, Arely; Satheesh, Agarsh; Mumtaz, Unza; Arruda-Carvalho, Maithe
Titel	Developmental Emergence of Persistent Memory for Contextual and Auditory Fear in Mice
Quelle	In: Learning & Memory, 28 (2021) 11, S.414-421 (8 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Arruda-Carvalho, Maithe)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
Schlagwörter	Memory; Animals; Fear; Conditioning; Auditory Stimuli; Gender Differences; Brain; Age Differences + Suchen Sie Ihr Suchwort? Gedächtnis; Animal; Tier; Tiere; Furcht; Auditive Stimulation; Geschlechterkonflikt; Gehirn; Age; Difference; Age difference; Altersunterschied
Abstract	The ability to generate memories that persist throughout a lifetime (that is, memory persistence) emerges in early development across species. Although it has been shown that persistent fear memories emerge between late infancy and adolescence in mice, it is unclear exactly when this transition takes place, and whether two major fear conditioning tasks, contextual and auditory fear, share the same time line of developmental onset. Here, we compared the ontogeny of remote contextual and auditory fear in C57BL/6J mice across early life. Mice at postnatal day (P)15, 21, 25, 28, and 30 underwent either contextual or auditory fear training and were tested for fear retrieval 1 or 30 d later. We found that mice displayed 30-d memory for context- and tone-fear starting at P25. We did not find sex differences in the ontogeny of either type of fear memory. Furthermore, 30-d contextual fear retrieval led to an increase in the number of c-Fos positive cells in the prelimbic region of the prefrontal cortex only at an age in which the contextual fear memory was successfully retrieved. These data delineate a precise time line for the emergence of persistent contextual and auditory fear memories in mice and suggest that the prelimbic cortex is only recruited for remote memory recall upon the onset of memory persistence. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01