DNA Methylation of the Oxytocin Receptor across Neurodevelopmental Disorders

Autor/inn/en	Siu, Michelle T.; Goodman, Sarah J.; Yellan, Isaac; Butcher, Darci T.; Jangjoo, Maryam; Grafodatskaya, Daria; Rajendram, Rageen; Lou, Youliang; Zhang, Rujun; Zhao, Chunhua; Nicolson, Rob; Georgiades, Stelios; Szatmari, Peter; Scherer, Stephen W.; Roberts, Wendy; Anagnostou, Evdokia; Weksberg, Rosanna
Titel	DNA Methylation of the Oxytocin Receptor across Neurodevelopmental Disorders
Quelle	In: Journal of Autism and Developmental Disorders, 51 (2021) 10, S.3610-3623 (14 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Weksberg, Rosanna)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-020-04792-x
Schlagwörter	Genetics; Autism; Pervasive Developmental Disorders; Biochemistry; Learning Disabilities; Behavior Problems; Patients; Behavior Disorders; Gender Differences; Comparative Analysis; Interpersonal Competence; Intelligence Quotient; Correlation; Outcomes of Treatment; Diagnostic Tests; Attention Deficit Hyperactivity Disorder + Suchen Sie Ihr Suchwort? Humangenetik; Autismus; Biochemie; Learning handicap; Lernbehinderung; Patient; Geschlechterkonflikt; Interpersonale Kompetenz; Intelligenzquotient; Korrelation; Diagnostic test; Diagnostischer Test
Abstract	Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, "OXTR," in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of "OXTR" was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that "OXTR" DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01